The NSF has recently sited its efforts to establish The Deep Underground Science and Engineering Laboratory (DUSEL) at the former Homestake Mine in Lead South Dakota following a three year examination of possible sites. I will review the status of the progress and process to establish DUSEL and highlight the physics experiments we anticipate to be constructed contemporaneously with the multidisciplinary research facility. Independently of the NSF DUSEL Process, the State of South Dakota is pursuing the creation of an interim laboratory, the Sanford Laboratory, in Homestake. This facility will become operational as early as next year. I will present these efforts and highlight the science program that is being prepared for installation in the Sanford Lab.